VIPM (Vascularized In vitro Perfusion Module)

Advanced Solutions Life Sciences patented and patent pending vascularization technologies provide a flexible, customizable, and effective approaches at integrating microvasculatures for in vitro assay, tissue fabrication, vascular model, and a variety of other applications.

Available as three different, vascularization product lines, our Microvessel Platform, In vitro Perfusion Module (IPM™), and Vascularized IPM™ (VIPM™) represent a complete vascularization solution addressing the need of a wide-spectrum of applications. The ability to recapitulate a microvascular perfusion in vitro, via the integration of rapidly fabricated microfluidic channels (IPM) and native microvasculatures (VIPM), has a significant impact in a number of areas. For example, in drug and therapeutics discovery and development, a vascularized tissue mimic with perfusion profoundly changes the predictive ability of screening assays. Additionally, incorporation of a perfused, functional microvasculature (Microvessel Platform), which is capable of adapting to match tissue-specific functionality, into tissue fabrication protocols fully enables the promise of regenerative medicine and tissue replacement approaches.

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RX1 BioPrinter

Bioprint complex functional tissue using the sophistication of microfluidics.

The RX1™ Bioprinter fabricates complex 3D tissues using our Lab-on-a-Printer™ technology, which provides unprecedented flexibility and control over 3D heterogeneous tissue fabrication. Designed with the biologist in mind, the RX1 offers open and flexible controls, compatibility with standard cell culture tools and standard biological safety cabinets, and an accessible and cleanable work area. The RX1™ is complemented by our set of biomaterials and series of printheads.

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3Dynamic Omega

3Dynamic Systems Omega Tissue Engineering Workstation is a dual extrusion 3D bioprinter used to generate heterogeneous tissues using a printable bioactive gel, protein growth factors and scaffolds which mature into living tissue structures. 3DS easy to use technology has been designed to allow for a greater adoption of bioprinting research and further innovation in the short-term by enabling researches in the field to effectively produce experimental tissues and multiple tissue types on demand.

The 3Dynamic Omega is a purely digital machine which is more effective at depositing complex biological-based fluids. By varying the deposition speed, the layer resolution can be altered. Additional methods using multiple biomaterials can also be used to integrate printed tissues with 3D scaffold fabrication. Various hydrogels-based materials can be used for depositing a scaffold, including fibrin, poly (lactide-co-glycolide) which is porous, agarose and alginate.

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3Dynamic Alpha

The 3Dynamic Alpha Series, is a single extrusion bone tissue fabrication platform. This is a research machine capable of depositing bone tissue materials. The 3DS Alpha can be used to accurately deposit bone composites in 3D, producing the correct anatomical geometry. This material can be seeded with platelet-derived growth factor to create the right environment for tissue regeneration by recruiting stem cells that can produce bone and forming a supportive structure, including blood vessels.

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BioAssemblyBOT

The patent pending BioAssemblyBot® robot arm gives you the freedom to 3D print advanced tissue structures and constructs. Take your biofabrication capability to a new level with:

• Additive 3D Printing
• Contour 3D Printing
• Pick & Place
• Assemble
• Interchangeable Tools
• Ease of Use with off the shelf Nordson® disposable syringes and a wide array of luer lock needle sizes
• Intuitive Touch Screen Interface
• Precision Temperature Control
• Seamless interface with TSIM® Software
• BioAssemblyBot® provides three areas of heating and cooling temperature control
  • Tool Storage Rack
  • While Connected to the Robot
  • Print Stage

BioAssemblyBot® maintains temperate control from 5 Celsius to 110 Celsius and can be adjusted during specific points in the 3D printing workflow.

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BioBOT – Basic

BioBot™ Basic provides an entry level technology platform for conducting 3D bioprinting research.
Specific features:

• Automated tip detect functionality
• Automated material change via turret assembly
• Automated pressure controls for pneumatic extrusion
• Can print structures requiring up to 5 materials or cell types
• 3-axis motion including rotational stage movement
• Stage leveling capabilities
• Works seamlessly with TSIM®
• TSIM® software has a BioBot™ tab, enabling progress/cancel functionality
• Swappable stage (includes flat stage and well-plate stage)

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BioFactory / RegenHU

The BioFactory™ is a versatile and cell friendly three-dimensional manufacturing instrument allowing scien- tists to pattern cells, bio-molecules and a range of soft and rigid materials in desirable 3D composite structures, mimicking natural environments. 
High-end solution for Industrial applications.

• Up to 8 printheads
• Printhead technology convergence
• Customization to user process

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Lumen X

Lumen X offers high resolution, high throughput and high fidelity – enhancing applications in microfluidics, cell-laden hydrogels, macroporous structures and more. Designed to bioprint vasculature with biocompatible blue light, Lumen X gives you a powerful advantage in achieving complex branching and tapering of vessels.

• Leverages over 1 million points of light to bioprint microscopic features down to 200 microns.
• Photographically cures entire layers at once to crosslink structures fifty times faster than other printing methods.
• Combines with CELLINK’s BIO X to multiply the benefits of each system’s state-of-the-art capabilities. You can use BIO X to print living cells within a Lumen X-fabricated structure and strengthen your work in applications like organ-on-a-chip and multimaterial research.

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I-DOT One

The “Immediate Drop on Demand Technology” (I-DOT) uses a patented non-contact, pressure-based dispensing technology. By applying a well-defined pressure pulse on top of a source microliter plate with holes in the bottom of each well, a droplet is formed and a highly precise and accurate nanoliter droplet is released into any target plate (SBS-compatible format). Larger volumes are achieved by applying up to 400 pulses per second. The I-DOT is a new approach for nanoliter to microliter liquid-handling tasks. The I-DOT One is specifically built for the use with 96 well I-DOT silica plates and I-DOT pure plates, where capillary forces keep the sample liquid in the cavity.

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HOLOGRAPH X

Holograph X leverages high-resolution holographic stereolithography to bioprint extremely small structures.

The proprietary multiphoton laser system prints biocompatible materials with up to 150,000 points of light per second to produce a user-generated structure. Users can rapidly print high-resolution structures that replicate human capillaries and ultra-fine extracellular matrices. The printing process is nontoxic and can be performed in the presence of cells.

• We use a high-energy laser to print a true-to-form holographic projection of a researcher-designed or developed 3D CAD file.
• The laser light projection of the 3D image is transmitted into a liquid biopolymer and crosslinked in milliseconds. After printing, the structures can be washed with PBS or water and used immediately.
• Printed structures have a shelf-life of up to six months at 4° C. The biopolymer is transplantable and compatible with extracellular matrix deposition.
• Structures can be seeded with numerous cell types and grown under standard tissue culture conditions.

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